Gnificant.ConclusionHere, we present evidence that IGFBP3 has dual, opposing effects on GIST cell viability and that IGFBP3 partially mediates the anti-tumor effects of imatinib mesylate in some GISTs in vitro. Further studies are needed to elucidate the mechanisms of IGFBP3 action and to evaluate IGFBP3 as a potential therapeutic agent or target in GISTs.cancer [31,49], and metastatic melanoma [5
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